In China，the short-range transportation of oils is mainly based on tanker transportation.Due to the influence of road conditions，especially in the process of turning，the tank will be subjected to strong dynamic loads during driving.Therefore，the coupling vibration of sloshing liquid and tank wall structure will be a very important problem.Based on ANSYS Workbench/Fluent finite element software，the harmonic response analysis of G₆₀ tank is carried out by unidirectional fluid-solid coupling.Considering that the tank body of the tanker will be subjected to the lateral impact load of the solution when turning，the impact load is simplified to a fixed acceleration.Under the action of this acceleration，the harmonic response analysis of the fluid-solid coupling system of the tank car under different filling rates is carried out.The result shows that when the tank body is impacted by a fixed impact，the maximum stress occurs at the connection between the tank body and the fully fixed support.With the increase of liquid filling rate，the stress at the same frequency also increases.