In order to prevent the occurrence of accidents in fine chemical industrial park,a multi-level hierarchical structure model of the influencing factors of vulnerability in fine chemical industrial park was proposed.Firstly,the index system of influencing factors of vulnerability is constructed from five aspects:personnel,facilities,materials,environment and management.Secondly,the decision laboratory analysis method was used to determine the correlation influence matrix,calculate the influence degree values among the vulnerability influencing factors,and analyze the complex internal relationship and accident path propagation.A multi-level hierarchical interpretive structural model based on DEMATEL-ISM was established.The results show that the professional skills of personnel,safety protection of equipment and storage of materials have direct influence on the vulnerability of the park.The implementation of laws and regulations and safety management system is the fundamental factor of vulnerability of the park,which provides reference for preventing accidents in fine chemical park from the root.