The application of different ionic liquids(ILs) in the separation of isopropyl acetate-isopropanol azeotropic mixture was investigated using the COSMO thermX software based on the COSMO-RS model.The effect of 396 ionic liquids composed of 18 cations and 22 anions on the separation of isopropyl acetate-isopropanol azeotrope was calculated and analyzed with the selectivity and viscosity of these ILs as indicators.The result indicated that ILs with［Ac］- anion had superior separation performance on isopropyl acetate isopropanol mixture.For cations，imidazolium-based ionic liquids exhibited higher selectivity and lower viscosity.Thus，1-hexyl-3-methylimidazolium acetate［HMIM］［Ac］ was selected as a preferred entrainer to the separation of isopropyl acetate-isopropanol azeotropic system.Finally，the excess enthalpy of component with［HMIM］［Ac］ and reduced density gradient method was performed to explore the separation mechanism of［HMIM］［Ac］.

Simulation of Separation of Ethyl Acetate——Isopropanol Azeotrope by Extractive Distillation [J]. Journal of Shenyang University of Chemical Technology, 2022, 36(6): 495-501.